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Los Angeles Rams vs Arizona Cardinals prediction, picks and odds

Back to the NFL Week 10 picks NFL picks Week 10 Sunday, November 15 · 4:05 PM ET State Farm Stadium, Glendale
Away · 5-4ML −455
4:05PM Kickoff Sun, Nov 15 · ET
ML +325Home · 3-6
SpreadLAR −9.5
Total39.5 points
Kickoff in4d 0h

State Farm Stadium

Updated 1:48 PM ET

Rams vs Cardinals picks

3 picks · Rams by 3 · 37 points
Moneyline
LAR ML−476 87%
The Rams win the game.
Confidence87%
Model69.1% SportsbooksOdds81.0% Edge−11.9
SpreadBest pick
ARI +16.5−256 78%
The Cardinals win, or lose by 16 points or fewer.
Confidence78%
Model74.1% SportsbooksOdds68.6% Edge+5.5
Total
Over 34.5odds up −213 76%
The two teams score 35 or more points between them.
Confidence76%
Model62.9% SportsbooksOdds68.6% Edge−5.7

Reading a pick: Sportsbooks is the win chance built into the odds when the pick went up, Model is our model’s own number, and Edge is the gap between them. Every pick is graded once the game is final.

Predicted score by quarter The model’s most likely score in each quarter, away team first
TeamQ1Q2Q3Q41st halfFinal
Rams60014620
Cardinals010071017
Most likely final scoresLAR 20–17 ARI 0.7%LAR 23–20 ARI 0.7%LAR 27–20 ARI 0.6%
Projected box score Model only Built from 20 full box scores per team · not a betting line
RamsCardinals

Offense

357 Total yards 323
230 Passing yards 222
127 Rushing yards 101
22 First downs 19

Scoring

2 Touchdowns 2
1 Passing touchdowns 1
1 Rushing touchdowns 1
2 Field goals made 1

Ball security

1 Turnovers 1
1 Interceptions thrown 1
1 Fumbles lost 1
2 Sacks allowed 2
55 Penalty yards 54
Team stat picks The model’s own lines on each team’s yards and first downs · no sportsbook odds
Total yards Over 310.5 Proj. 357 72%
Passing yards Over 188.5 Proj. 230 72%
Rushing yards Over 98.5 Proj. 127 72%
First downs Over 19.5 Proj. 22 69%
Total yards Over 276.5 Proj. 323 72%
Passing yards Over 180.5 Proj. 222 72%
Rushing yards Over 72.5 Proj. 101 72%
First downs Over 16.5 Proj. 19 71%
Key players Projected lines for each team’s quarterback, running back and top receivers
Rams
QB Matthew Stafford22/34 · 230 pass yds · 1.0 TD · 0.7 INT 230pass yds
RB Kyren Williams16 carries · 66 rush yds · 0.5 TD · 3 rec 66rush yds
WR/TE Puka Nacua9 rec · 102 yds · 0.4 TD 102rec yds
WR/TE Colby Parkinson3 rec · 22 yds · 0.1 TD 22rec yds
Cardinals
QB Gardner Minshew19/26 · 190 pass yds · 1.0 TD · 0.0 INT 190pass yds
RB Tyler Allgeier11 carries · 47 rush yds · 1.0 TD · 2 rec 47rush yds
WR/TE Trey McBride7 rec · 66 yds · 0.4 TD 66rec yds
WR/TE Michael Wilson5 rec · 65 yds · 0.1 TD 65rec yds

The Los Angeles Rams visit the Arizona Cardinals in NFL Week 10 of the 2026 season, on Sunday, November 15 at 4:05 PM ET, at State Farm Stadium, Glendale. The Rams come in at 5-4 and the Cardinals at 3-6. The moneyline has the Rams at −455 and the Cardinals at +325.

Our model predicts a final score of Rams 20, Cardinals 17. Its picks: the Rams to win (−476); the Cardinals +16.5 (−256); over 34.5 points (−213). The best pick is the Cardinals +16.5, at 78% confidence.