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Miami Dolphins vs Indianapolis Colts prediction, picks and odds

Back to the NFL Week 10 picks NFL picks Week 10 Sunday, November 15 · 1:00 PM ET Lucas Oil Stadium, Indianapolis
Away · 1-7ML +163
1:00PM Kickoff Sun, Nov 15 · ET
ML −204Home · 2-7
SpreadIND −3.5
Total38.5 points
Kickoff in3d 21h

Lucas Oil Stadium

Updated 1:48 PM ET

Dolphins vs Colts picks

3 picks · Colts by 3 · 37 points
Moneyline
IND MLodds down −204 69%
The Colts win the game.
Confidence69%
Model59.6% SportsbooksOdds55.6% Edge+4.0
Spread
IND +3.5odds down −303 77%
The Colts win, or lose by three points or fewer.
Confidence77%
Model71.6% SportsbooksOdds67.2% Edge+4.4
TotalBest pick
Over 35.5odds up −164 77%
The two teams score 36 or more points between them.
Confidence77%
Model76.9% SportsbooksOdds68.1% Edge+8.8

Reading a pick: Sportsbooks is the win chance built into the odds when the pick went up, Model is our model’s own number, and Edge is the gap between them. Every pick is graded once the game is final.

Predicted score by quarter The model’s most likely score in each quarter, away team first
TeamQ1Q2Q3Q41st halfFinal
Dolphins37701017
Colts010731020
Most likely final scoresMIA 17–20 IND 0.9%MIA 24–27 IND 0.8%MIA 20–23 IND 0.7%
Projected box score Model only Built from 20 full box scores per team · not a betting line
DolphinsColts

Offense

318 Total yards 318
191 Passing yards 200
127 Rushing yards 118
17 First downs 19

Scoring

2 Touchdowns 2
1 Passing touchdowns 1
1 Rushing touchdowns 1
1 Field goals made 2

Ball security

1 Turnovers 1
1 Interceptions thrown 1
1 Fumbles lost 1
2 Sacks allowed 2
55 Penalty yards 52
Team stat picks The model’s own lines on each team’s yards and first downs · no sportsbook odds
Total yards Over 271.5 Proj. 318 72%
Passing yards Over 149.5 Proj. 191 72%
Rushing yards Over 98.5 Proj. 127 72%
First downs Over 14.5 Proj. 17 73%
Total yards Over 271.5 Proj. 318 72%
Passing yards Over 158.5 Proj. 200 72%
Rushing yards Over 89.5 Proj. 118 72%
First downs Over 16.5 Proj. 19 71%
Key players Projected lines for each team’s quarterback, running back and top receivers
Dolphins
QB Malik Willis16/28 · 191 pass yds · 1.0 TD · 0.7 INT 191pass yds
RB Ollie Gordon17 carries · 76 rush yds · 0.7 TD · 1 rec 76rush yds
WR/TE Caleb Douglas4 rec · 64 yds · 0.5 TD 64rec yds
WR/TE Greg Dulcich4 rec · 51 yds · 0.0 TD 51rec yds
Colts
QB Daniel Jones20/30 · 200 pass yds · 1.0 TD · 0.8 INT 200pass yds
RB Jonathan Taylor16 carries · 65 rush yds · 0.6 TD · 3 rec 65rush yds
WR/TE Keenan Allen6 rec · 58 yds · 0.0 TD 58rec yds
WR/TE Josh Downs3 rec · 34 yds · 0.3 TD 34rec yds

The Miami Dolphins visit the Indianapolis Colts in NFL Week 10 of the 2026 season, on Sunday, November 15 at 1:00 PM ET, at Lucas Oil Stadium, Indianapolis. The Dolphins come in at 1-7 and the Colts at 2-7. The moneyline has the Dolphins at +163 and the Colts at −204.

Our model predicts a final score of Dolphins 17, Colts 20. Its picks: the Colts to win (−204); the Colts +3.5 (−303); over 35.5 points (−164). The best pick is over 35.5 points, at 77% confidence.