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Washington Commanders vs San Francisco 49ers prediction, picks and odds

Back to this week’s NFL picks NFL picks Week 6 Monday, October 19 · 8:15 PM ET · ESPN Levi's Stadium, Santa Clara
1-3-1 · Away
17–23 Final Predicted 20–23
5-0 · Home
Score by quarter
TeamQ1Q2Q3Q4T
WAS307717
SF1373023
COMMANDERS 28% Pre-game win chance 72% 49ERS

SF by 3 · 43 points

Updated Oct 19, 11:37 PM ET

Commanders vs 49ers picks

3 picks · 49ers by 3 · 43 points · 3 of 3 won
Moneyline
SF MLodds up −400 Won 93%
The 49ers win the game.
Confidence93%
Model72.4% SportsbooksOdds78.9% Edge−6.5
SpreadBest pick
WAS +14.5odds down −270 Won 78%
The Commanders win, or lose by 14 points or fewer.
Confidence78%
Model67.8% SportsbooksOdds69.2% Edge−1.4
Total
Under 57odds up −208 Won 76%
The two teams score 56 or fewer points between them (exactly 57 is a push).
Confidence76%
Model69.7% SportsbooksOdds69.9% Edge−0.2

Reading a pick: Sportsbooks is the win chance built into the odds when the pick went up, Model is our model’s own number, and Edge is the gap between them. Every pick is graded once the game is final.

Predicted score by quarter The model’s most likely score in each quarter, away team first
TeamQ1Q2Q3Q41st halfFinal
Commanders0101001020
49ers0977923
Most likely final scoresWAS 20–23 SF 0.6%WAS 24–27 SF 0.6%WAS 20–27 SF 0.5%
Projected box score Model only Built from 20 full box scores per team · not a betting line
Commanders49ers

Offense

307▲ 314 Total yards ▲ 375356
189▲ 261 Passing yards ▲ 249239
118▼ 53 Rushing yards ▲ 126117
18▲ 19 First downs ▼ 2021

Scoring

2= 2 Touchdowns = 33
1▲ 2 Passing touchdowns ▼ 12
1▼ 0 Rushing touchdowns ▲ 21
2▼ 1 Field goals made = 11

Ball security

1▼ 0 Turnovers = 11
1▼ 0 Interceptions thrown ▼ 01
1▼ 0 Fumbles lost = 11
2▲ 4 Sacks allowed = 22
51▲ 66 Penalty yards ▲ 8849
Team stat picks The model’s own lines on each team’s yards and first downs · no sportsbook odds
Total yards Over 260.5 Proj. 307 72% Won · 314
Passing yards Over 147.5 Proj. 189 72% Won · 261
Rushing yards Over 89.5 Proj. 118 72% Lost · 53
First downs Over 15.5 Proj. 18 69% Won · 19
Total yards Over 309.5 Proj. 356 72% Won · 375
Passing yards Over 198.5 Proj. 240 72% Won · 249
Rushing yards Over 88.5 Proj. 117 72% Won · 126
First downs Over 18.5 Proj. 21 71% Won · 20
Key players Projected lines for each team’s quarterback, running back and top receivers
Commanders
QB Jayden Daniels16/26 · 159 pass yds · 0.8 TD · 0.0 INT 159pass yds
RB Jacory Merritt12 carries · 40 rush yds · 0.5 TD · 1 rec 40rush yds
WR/TE Terry McLaurin4 rec · 53 yds · 0.1 TD 53rec yds
WR/TE Antonio Williams3 rec · 31 yds · 0.1 TD 31rec yds
49ers
QB Brock Purdy22/33 · 239 pass yds · 2.0 TD · 0.7 INT 239pass yds
RB Christian McCaffrey12 carries · 52 rush yds · 0.8 TD · 4 rec 52rush yds
WR/TE Mike Evans5 rec · 66 yds · 0.5 TD 66rec yds
WR/TE George Kittle5 rec · 54 yds · 0.6 TD 54rec yds

The San Francisco 49ers beat the Washington Commanders 23–17 in NFL Week 6 of the 2026 season (Monday Night Football on ESPN), on Monday, October 19 at 8:15 PM ET, at Levi's Stadium, Santa Clara. The moneyline had the Commanders at +310 and the 49ers at −385.

Our model predicted a final score of Commanders 20, 49ers 23. Its picks: the 49ers to win (−400), won; the Commanders +14.5 (−270), won; under 57 points (−208), won. The best pick was the Commanders +14.5, at 78% confidence.