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San Francisco 49ers vs Dallas Cowboys prediction, picks and odds

Back to the NFL Week 10 picks NFL picks Week 10 Sunday, November 15 · 4:25 PM ET AT&T Stadium, Arlington
Away · 7-1ML −213
4:25PM Kickoff Sun, Nov 15 · ET
ML +170Home · 4-5
SpreadSF −3.5
Total55.5 points
Kickoff in4d 0h

AT&T Stadium

Updated 1:48 PM ET

49ers vs Cowboys picks

3 picks · 49ers by 3 · 51 points
Moneyline
SF MLodds up −217 64%
The 49ers win the game.
Confidence64%
Model56.9% SportsbooksOdds67.0% Edge−10.1
SpreadBest pick
DAL +9.5odds up −250 78%
The Cowboys win, or lose by nine points or fewer.
Confidence78%
Model73.7% SportsbooksOdds68.6% Edge+5.1
Total
Under 62.5odds up −244 77%
The two teams score 62 or fewer points between them.
Confidence77%
Model77.2% SportsbooksOdds68.6% Edge+8.6

Reading a pick: Sportsbooks is the win chance built into the odds when the pick went up, Model is our model’s own number, and Edge is the gap between them. Every pick is graded once the game is final.

Predicted score by quarter The model’s most likely score in each quarter, away team first
TeamQ1Q2Q3Q41st halfFinal
49ers0101071027
Cowboys107071724
Most likely final scoresSF 27–24 DAL 0.8%SF 30–27 DAL 0.7%SF 20–17 DAL 0.7%
Projected box score Model only Built from 20 full box scores per team · not a betting line
49ersCowboys

Offense

367 Total yards 335
230 Passing yards 235
137 Rushing yards 100
21 First downs 20

Scoring

3 Touchdowns 3
2 Passing touchdowns 2
1 Rushing touchdowns 1
2 Field goals made 1

Ball security

1 Turnovers 1
1 Interceptions thrown 1
1 Fumbles lost 1
2 Sacks allowed 2
56 Penalty yards 55
Team stat picks The model’s own lines on each team’s yards and first downs · no sportsbook odds
Total yards Over 320.5 Proj. 367 72%
Passing yards Over 188.5 Proj. 230 72%
Rushing yards Over 109.5 Proj. 138 72%
First downs Over 18.5 Proj. 22 73%
Total yards Over 288.5 Proj. 335 72%
Passing yards Over 194.5 Proj. 236 72%
Rushing yards Over 71.5 Proj. 100 72%
First downs Over 17.5 Proj. 20 72%
Key players Projected lines for each team’s quarterback, running back and top receivers
49ers
QB Brock Purdy21/32 · 230 pass yds · 2.0 TD · 0.7 INT 230pass yds
RB Christian McCaffrey13 carries · 62 rush yds · 0.8 TD · 5 rec 62rush yds
WR/TE George Kittle6 rec · 62 yds · 0.7 TD 62rec yds
WR/TE Jordan Watkins3 rec · 49 yds · 0.3 TD 49rec yds
Cowboys
QB Dak Prescott24/35 · 235 pass yds · 2.0 TD · 0.7 INT 235pass yds
RB Javonte Williams18 carries · 71 rush yds · 0.8 TD · 3 rec 71rush yds
WR/TE CeeDee Lamb8 rec · 87 yds · 0.9 TD 87rec yds
WR/TE Ryan Flournoy4 rec · 48 yds · 0.4 TD 48rec yds

The San Francisco 49ers visit the Dallas Cowboys in NFL Week 10 of the 2026 season, on Sunday, November 15 at 4:25 PM ET, at AT&T Stadium, Arlington. The 49ers come in at 7-1 and the Cowboys at 4-5. The moneyline has the 49ers at −213 and the Cowboys at +170.

Our model predicts a final score of 49ers 27, Cowboys 24. Its picks: the 49ers to win (−217); the Cowboys +9.5 (−250); under 62.5 points (−244). The best pick is the Cowboys +9.5, at 78% confidence.