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New England Patriots vs Detroit Lions prediction, picks and odds

Back to the NFL Week 10 picks NFL picks Week 10 Sunday, November 15 · 9:30 AM ET FC Bayern Munich Stadium (neutral site)
Away · 5-4ML +130
9:30AM Kickoff Sun, Nov 15 · ET
ML −161Home · 6-2
SpreadDET −2.5
Total50.5 points
Kickoff in3d 18h

FC Bayern Munich Stadium (neutral site)

Updated 1:48 PM ET

Patriots vs Lions picks

3 picks · Lions by 3 · 37 points
Moneyline
DET MLodds up −159 54%
The Lions win the game.
Confidence54%
Model52.4% SportsbooksOdds59.1% Edge−6.7
SpreadBest pick
NE +7.5odds up −278 78%
The Patriots win, or lose by seven points or fewer.
Confidence78%
Model74.2% SportsbooksOdds71.0% Edge+3.2
Total
Under 57.5−250 77%
The two teams score 57 or fewer points between them.
Confidence77%
Model72.6% SportsbooksOdds68.1% Edge+4.5

Reading a pick: Sportsbooks is the win chance built into the odds when the pick went up, Model is our model’s own number, and Edge is the gap between them. Every pick is graded once the game is final.

Predicted score by quarter The model’s most likely score in each quarter, away team first
TeamQ1Q2Q3Q41st halfFinal
Patriots00107017
Lions0100101020
Most likely final scoresNE 17–20 DET 0.8%NE 20–23 DET 0.8%NE 24–27 DET 0.8%
Projected box score Model only Built from 20 full box scores per team · not a betting line
PatriotsLions

Offense

356 Total yards 353
248 Passing yards 240
108 Rushing yards 113
20 First downs 20

Scoring

2 Touchdowns 2
1 Passing touchdowns 1
1 Rushing touchdowns 1
1 Field goals made 2

Ball security

1 Turnovers 1
1 Interceptions thrown 1
1 Fumbles lost 1
3 Sacks allowed 3
53 Penalty yards 52
Team stat picks The model’s own lines on each team’s yards and first downs · no sportsbook odds
Total yards Over 309.5 Proj. 356 72%
Passing yards Over 206.5 Proj. 248 72%
Rushing yards Over 79.5 Proj. 108 72%
First downs Over 17.5 Proj. 20 72%
Total yards Over 306.5 Proj. 353 72%
Passing yards Over 199.5 Proj. 241 72%
Rushing yards Over 84.5 Proj. 113 72%
First downs Over 17.5 Proj. 21 73%
Key players Projected lines for each team’s quarterback, running back and top receivers
Patriots
QB Drake Maye22/33 · 248 pass yds · 1.0 TD · 0.8 INT 248pass yds
RB Rhamondre Stevenson11 carries · 41 rush yds · 0.3 TD · 3 rec 41rush yds
WR/TE Hunter Henry4 rec · 44 yds · 0.1 TD 44rec yds
WR/TE Efton Chism III3 rec · 30 yds · 0.1 TD 30rec yds
Lions
QB Jared Goff22/32 · 240 pass yds · 1.0 TD · 0.7 INT 240pass yds
RB Jahmyr Gibbs20 carries · 91 rush yds · 0.9 TD · 4 rec 91rush yds
WR/TE Amon-Ra St. Brown7 rec · 71 yds · 0.1 TD 71rec yds
WR/TE Jameson Williams4 rec · 62 yds · 0.6 TD 62rec yds

The New England Patriots visit the Detroit Lions in NFL Week 10 of the 2026 season, on Sunday, November 15 at 9:30 AM ET, at FC Bayern Munich Stadium (neutral site). The Patriots come in at 5-4 and the Lions at 6-2. The moneyline has the Patriots at +130 and the Lions at −161.

Our model predicts a final score of Patriots 17, Lions 20. Its picks: the Lions to win (−159); the Patriots +7.5 (−278); under 57.5 points (−250). The best pick is the Patriots +7.5, at 78% confidence.