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Indianapolis Colts vs Pittsburgh Steelers prediction, picks and odds

Back to this week’s NFL picks NFL picks Week 5 Sunday, October 11 · 1:00 PM ET Acrisure Stadium, Pittsburgh
2-2 · Away
22–34 Final Predicted 23–20
2-2 · Home
Score by quarter
TeamQ1Q2Q3Q4T
IND676322
PIT71071034
COLTS 51% Pre-game win chance 49% STEELERS

IND by 3 · 43 points

Updated Oct 11, 4:19 PM ET

Colts vs Steelers picks

3 picks · Colts by 3 · 43 points · 1 of 3 won
Moneyline
IND MLodds up +129 Lost 52%
The Colts win the game.
Confidence52%
Model50.8% SportsbooksOdds42.8% Edge+8.0
SpreadBest pick
IND +7.5odds up −256 Lost 85%
The Colts win, or lose by seven points or fewer.
Confidence85%
Model76.7% SportsbooksOdds71.5% Edge+5.2
Total
Over 37.5odds up −200 Won 85%
The two teams score 38 or more points between them.
Confidence85%
Model71.0% SportsbooksOdds68.9% Edge+2.1

Reading a pick: Sportsbooks is the win chance built into the odds when the pick went up, Model is our model’s own number, and Edge is the gap between them. Every pick is graded once the game is final.

Predicted score by quarter The model’s most likely score in each quarter, away team first
TeamQ1Q2Q3Q41st halfFinal
Colts06314623
Steelers0101001020
Most likely final scoresIND 23–20 PIT 0.9%IND 30–27 PIT 0.6%IND 27–20 PIT 0.5%
Projected box score Model only Built from 20 full box scores per team · not a betting line
ColtsSteelers

Offense

315▲ 332 Total yards ▲ 352347
205▲ 266 Passing yards ▼ 225236
110▼ 66 Rushing yards ▲ 127111
19= 19 First downs ▼ 1620

Scoring

3▼ 1 Touchdowns ▲ 42
2▼ 0 Passing touchdowns ▲ 31
1= 1 Rushing touchdowns = 11
1▲ 5 Field goals made = 22

Ball security

1▼ 0 Turnovers ▼ 01
1▼ 0 Interceptions thrown ▼ 01
0= 0 Fumbles lost = 00
2▼ 1 Sacks allowed ▼ 12
49▲ 59 Penalty yards ▼ 5051
Team stat picks The model’s own lines on each team’s yards and first downs · no sportsbook odds
Total yards Over 268.5 Proj. 315 72% Won · 332
Passing yards Over 164.5 Proj. 206 72% Won · 266
Rushing yards Over 81.5 Proj. 110 72% Lost · 66
First downs Over 15.5 Proj. 19 75% Won · 19
Total yards Over 300.5 Proj. 347 72% Won · 352
Passing yards Over 194.5 Proj. 236 72% Won · 225
Rushing yards Over 83.5 Proj. 112 72% Won · 127
First downs Over 17.5 Proj. 20 69% Lost · 16
Key players Projected lines for each team’s quarterback, running back and top receivers
Colts
QB Daniel Jones21/32 · 205 pass yds · 2.0 TD · 0.8 INT 205pass yds
RB Jonathan Taylor20 carries · 88 rush yds · 0.9 TD · 2 rec 88rush yds
WR/TE Josh Downs4 rec · 59 yds · 0.0 TD 59rec yds
WR/TE Tyler Warren6 rec · 38 yds · 1.3 TD 38rec yds
Steelers
QB Aaron Rodgers22/35 · 236 pass yds · 1.0 TD · 0.7 INT 236pass yds
RB Jaylen Warren16 carries · 91 rush yds · 0.0 TD · 3 rec 91rush yds
WR/TE DK Metcalf4 rec · 56 yds · 0.1 TD 56rec yds
WR/TE Roman Wilson3 rec · 50 yds · 0.3 TD 50rec yds

The Pittsburgh Steelers beat the Indianapolis Colts 34–22 in NFL Week 5 of the 2026 season, on Sunday, October 11 at 1:00 PM ET, at Acrisure Stadium, Pittsburgh. The moneyline had the Colts at +131 and the Steelers at −161.

Our model predicted a final score of Colts 23, Steelers 20. Its picks: the Colts to win (+129), lost; the Colts +7.5 (−256), lost; over 37.5 points (−200), won. The best pick was the Colts +7.5, at 85% confidence.